Al Gharafa's impressive 4-2 win against Al Ain FC of the UAE was undone by their 2-1 defeat to Al Wasl on Matchday Three and the Qatar side have to bounce back if they are to stay on track for the next stage.

The records, however, are against them as Al Gharafa have lost their last four away matches (including neutral venues) on the continental stage.

Persepolis will be equally desperate to revive their campaign, with the two-time AFC Champions League™ runners-up still seeking their first win of the season.

The 1-0 defeat to Qatar's Al Sadd SC on Matchday Three extended their winless run on the continent to six games, their longest stretch ever without a victory.

Venue: Al Maktoum Stadium (Dubai)

Kick-off: 20:00 (UTC+4)