FC Ravshan (TJK) v Tractor FC (IRN) 

FC Ravshan will look to kick start their campaign when they welcome Tractor FC to Dushanbe's Central Republican Stadium.

The Tajikistan side suffered a 1-0 defeat to Qatar's Al Wakrah SC last time out and another loss on Wednesday will see them six points behind Islamic Republic of Iran's Tractor FC. 

Venue: Central Republican Stadium, Dushanbe

Kick-off: Wednesday, 19:00 (UTC+5)

Al Taawoun FC (KSA) v Altyn Asyr (TKM)

Air Force SC (IRQ) v Al Khaldiya SC (BHR)

Air Force SC will be seeking a third consecutive win as the Iraqi club look to add the AFC Champions League Two title to the three AFC Cup™ crowns already in their possession.

They welcome Al Khaldiya SC to the Al Madina International Stadium with the Bahraini club needing victory to draw level with Air Force SC on six points. 

Al Taawoun FC will also be in search of a win when they host Altyn Asyr, after having suffered a 2-1 defeat to Air Force SC on Matchday Two. 

Turkmenistan's Altyn Asyr will, however, try to mount a challenge after having suffered defeats in their opening matches. 

Venue: Wolves Park, Buraidah

Kick-off: Wednesday, 21:00 (UTC+3) 

Venue: Al Madina International Stadium, Baghdad

Kick-off: Wednesday, 21:00 (UTC+3)

FC Istiklol (TJK) v Al Wehdat (JOR)

Sharjah FC (UAE) v Sepahan FC (IRN) - 

Al Wehdat and Sharjah FC will aim to further tighten their grip on Group C when they face FC Istiklol and Sepahan FC respectively on Tuesday.

Both are level on four points, with Jordan's Al Wehdat ahead on goal difference.

Al Wehdat will fancy their chances against FC Istiklol, with the side from Tajikistan having suffered defeats in their first two matches, while Sharjah can expect Sepahan FC to be tough competitors as the Iranian side look to leapfrog Tuesday's opponents in the standings. 

Venue: Republic Central Stadium, Dushanbe

Kick-off: Tuesday, 19:00 (UTC+5)

Sharjah FC (UAE) v Sepahan FC (IRN)  

Venue: Sharjah Stadium, Sharjah

Kick-off: Tuesday, 18:00 (UTC+4)

Al Hussein (JOR) v PFC Nasaf (UZB) 

Shabab Al Ahli (UAE) v Kuwait SC (KUW) 

Al Hussein will be aiming to overtake PFC Nasaf in the Group D standings when the two sides face off in Amman.

Jordan's Al Hussein are a point behind group leaders Nasaf of Uzbekistan, as are UAE's Shabab Al Ahli, who face Kuwait SC.

Kuwait SC, who are on two points, are also very much in the mix which ensures a thrilling Matchday in Group D. 

Venue: Amman International Stadium, Amman

Kick-off: Wednesday, 19:00 (UTC+3)

Venue: Rashid Stadium, Dubai

Kick-off: Wednesday, 20:00 (UTC+4)

Kaya FC-Iloilo (PHI) v Eastern (HKG) 

Sanfrecce Hiroshima (JPN) v Sydney FC (AUS) 

It will be a top-of-the-table clash when Japan's Sanfrecce Hiroshima welcome Sydney FC of Australia on Thursday with both sides on a perfect six points. 

Victory for either will boost their Round of 16 hopes, setting the stage for a thrilling contest.

Kaya FC-Iloilo of the Philippines will host Hong Kong's Eastern with both sides needing a win after having opened their respective campaigns with two defeats. 

Venue: Rizal Memorial Stadium, Manila

Kick-off: Thursday, 20:00 (UTC+8)

Venue: Hiroshima Soccer Stadium, Hiroshima

Kick-off: Wednesday, 19:00 (UTC+9)

Port FC (THA) v Zhejiang FC (CHN) 

Persib Bandung (IDN) v Lion City Sailors FC (SGP) 

With their Matchday Two tie postponed due to adverse weather conditions, Port FC of Thailand and Singapore's Lion City Sailors will target wins on Thursday. 

Port FC will play China PR's Zhejiang FC, with both teams on three points, while Lion City Sailors will travel for their encounter with Persib Bandung, with the Indonesian side desperate to reverse their fortunes after two defeats. 

Venue: Pathum Thani Stadium, Pathum Thani 

Kick-off: Thursday, 19:00 (UTC+7)

Venue: Si Jalak Harupat Stadium, Soreang

Kick-off: Thursday, 19:00 (UTC+7)

Lee Man (HKG) v Bangkok United (THA) 

Tampines Rovers (SGP) v Nam Dinh FC (VIE) 

Hong Kong's Lee Man will be out to stop their losing streak when they face table-toppers Bangkok United on Thursday. 

The Thai side lead the standings ahead of Vietnam's Nam Dinh FC on goal difference, with both on four points.

Nam Dinh face a potentially tricky away tie against Tampines Rovers FC, with the Singaporean side seeking a win that would move them up to six points. 

Venue: Mong Kok Stadium, Hong Kong 

Kick-off: Thursday, 18:00 (UTC+8)

Venue: Jalan Besar Stadium, Singapore 

Kick-off: Thursday, 20:00 (UTC+8)

Selangor FC (MAS) v Jeonbuk Hyundai Motors FC (KOR) 

Muangthong United FC (THA) v Dynamic Herb Cebu FC (PHI) 

Selangor FC will hope to upstage Jeonbuk Hyundai Motors FC when they welcome the two-time AFC Champions League™ winners to the MBPJ Stadium on Wednesday.

A win for the Malaysian side will see them overtaking Jeonbuk in the standings, with the Korea Republic outfit having won their opening two matches. 

Thailand's Muangthong United FC meet Dynamic Herb Cebu FC of the Philippines with victory the only option for both in their bid to stay in the race for a knockout stage spot. 

Venue: MBPJ Stadium, Petaling Jaya

Kick-off: Wednesday, 20:00 (UTC+8)

Venue: Rajamangala Stadium, Bangkok 

Kick-off: Wednesday, 19:00 (UTC+7)