Group A
Kuwait SC (KUW) v PFC Nasaf (UZB)
Venue: Jaber Al-Mubarak Al-Sabah Stadium (Sulaibikhat)
Kick-off: Wednesday, 19:00 (UTC+3)

Al Wahda FC (UAE) v Al Khaldiya SC (BHR)
Venue: Al Nahyan Stadium (Abu Dhabi)
Kick-off: Wednesday, 20:00 (UTC+4)

Al Wahda FC and Kuwait SC will confirm progression to the Round of 16 with victories in their respective Group A matches.

UAE's Al Wahda lead the standings with a perfect nine points and a win against Bahrain's Al Khaldiya SC - who only have a draw from their earlier matches - will assure their Round of 16 spot with two games to spare.

Kuwait SC - on six points - will also book their spot with two matches to spare with victory over PFC Nasaf and Al Khaldiya losing to Al Wahda.

Victory is the only option for Uzbekistan's Nasaf, who are on one point.

Group B
FC Arkadag (TKM) v Golgohar Sirjan SC (IRN)
Venue: Arkadag Stadium (Arkadag)
Kick-off: Wednesday, 18:45 (UTC+5)

Al Muharraq SC (BHR) v Al Jazira Club (UAE)
Venue: Bahrain National Stadium (Riffa)
Kick-off: Wednesday, 21:15 (UTC+3)

Al Jazira Club are also well placed after three matchdays, with the UAE side on seven points.

Victory for them against Al Muharraq SC and defeat for Golgohar Sirjan SC will ensure UAE's Al Jazira progression.

Bahrain's Al Muharraq are on three points while Islamic Republic of Iran's Golgohar are one adrift.

Golgohar, however, will be firmly back in the running if they defeat FC Arkadag as it would take them within a point of the Turkmenistan side.

Group C
Al Rayyan SC (QAT) v Al Nahda (OMA) Venue: Ahmad Bin Ali Stadium (Al Rayyan)
Kick-off: Wednesday, 19:00 (UTC+3)

Al Taawoun (KSA) v Al Faisaly (JOR)
Venue: Wolves Park (Buraidah)
Kick-off: Wednesday, 21:15 (UTC+3)

Al Taawoun FC will confirm their spot in the knockout stage if they defeat Al Faisaly and Al Nahda fail to beat Al Rayyan SC.

Saudi Arabia's Al Taawoun are on seven points, with Qatar's Al Rayyan one behind.

Jordan's Al Faisaly have three points while Oman's Al Nahda are two adrift, with victory for Al Rayyan almost surely confirming their progression to the next round.

Group D
East Bengal FC (IND) v Al Seeb Club (OMA)
Venue: Vivekananda Yuba Bharati Krirangan (Kolkata)
Kick-off: Tuesday, 19:15 (UTC+5:30)

Al Hussein (JOR) v Al Shorta (IRQ)
Venue: Amman International Stadium (Amman)
Kick-off: Tuesday, 19:00 (UTC+3)

Al Shorta will take a huge step towards the Round of 16 if they defeat Al Hussein in their top of the table clash.

Iraq's Al Shorta picked up seven points from their first three matches, with Jordan's Al Hussein trailing them by two.

East Bengal FC will host Al Seeb Club in a must-win encounter for both teams.

India's East Bengal have two points while Oman's Al Nahda are one behind.

Group E
Melbourne Victory (AUS) v Persib Bandung (IDN)
Venue: Melbourne Rectangular Stadium (Melbourne)
Kick-off: Wednesday, 18:45 (UTC+11)

FC Seoul (KOR) v The Cong - Viettel FC (VIE)
Venue: Seoul World Cup Stadium (Seoul)
Kick-off: Wednesday, 19:00 (UTC+9)

Melbourne Victory will be aiming to spoil Persib Bandung's party when the sides meet in their top of the table clash.

Australia's Melbourne are on four points, five behind Persib who have a perfect record of three wins and a fourth consecutive victory will confirm their Round of 16 spot.

FC Seoul revived their campaign with an impressive 5-0 win against The Cong - Viettel FC and the newly-crowned Korea Republic champions will seek to do the double against their Vietnamese opponents to keep their knockout stage hopes alive.

Group F
Lion City Sailors FC (SGP) v Adelaide United FC (AUS)
Venue: Jalan Besar Stadium (Singapore)
Kick-off: Thursday, 18:00 (UTC+8)

BG Pathum United (THA) v Tai Po FC (HKG)
Venue: Pathum Thani Stadium (Hong Kong)
Kick-off: Thursday, 20:15 (UTC+8)

Lion City Sailors FC will aim to complete the double over Adelaide United when the sides clash for the second time in a week.

The Sailors cruised to a 2-0 win over Adelaide on Matchday Three and victory again will almost surely confirm the Singapore's side's Round of 16 ticket.

They are on seven points, one ahead of Adelaide, with BG Pathum United a further two adrift.

Thailand's Pathum United revived their hopes with victory against Tai Po FC last week and another win against the Hong Kong, China side will keep them firmly in the race to advance.

Group G
FC Machida Zelvia (JPN) v Shanghai Shenhua FC
Venue: Machida Stadium (Machida)
Kick-off: Thursday, 19:00 (UTC+9)

Preah Khan Reach Svay Rieng FC (CAM) v Tampines Rovers FC (SGP)
Venue: Morodok Techo National Stadium (Phnom Penh)
Kick-off: Thursday, 19:15 (UTC+7)

FC Machida Zelvia are all but sure of advancing to the next stage, with the Japanese side on a perfect nine points heading into Matchday Four.

They are five points ahead of Preah Khan Reach Svay Rieng FC and Shanghai Shenhua FC, and only a disaster will prevent last season's AFC Champions League Elite™ runners-up from booking their ticket to the Round of 16.

They face Shenhua at home, with the China PR side needing victory to stay in the race.

So do Svay Rieng and the Cambodian side will fancy their chances against Tampines Rovers FC, with the Singapore outfit having yet to register points on the board.

Group H
Kitchee SC (HKG) v Phnom Penh Crown FC (CAM)
Venue: Mong Kok Stadium (Hong Kong)
Kick-off: Thursday, 18:00 (UTC+8)

Kuching City FC (MAS) v Gangwon FC (KOR)
Venue: Stadium Taha Ariffin (Kuching)
Kick-off: Thursday, 20:15 (UTC+8)

Late goals steered Phnom Penh Crown FC to victory on Matchday Three, with the result almost surely taking them through to the Round of 16.

The Cambodian side defeated Kitchee SC 2-0 and another win in the reverse fixture will make it four victories on the trot.

Hong Kong, China's Kitchee, however, need a win to stay in the race as they sit two points behind Gangwon FC, with the top two teams advancing.

Korea Republic's Gangwon travel to play Kuching City FC, with the Malaysian side on a single point and in desperate need of victory.